Oncogenes calling on a lysosomal Ca 2+ channel
نویسندگان
چکیده
منابع مشابه
Maitotoxin , a Ca 2 + Channel Activator
Effects of maitotoxin, the most potent marine toxin, were studied using a rat pheochromocytoma cell line, PC12h. A low concentration (lo-* g/ml) of maitotoxin induced a profound increase in Ca2+ influx into PC12h cells and the Ca2+-dependent release of [3H]norepinephrine from them. The effects of maitotoxin were not affected by treatment with tetrodotoxin M) and were observed even in the ab...
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PURPOSE Acidic organelles, including Golgi bodies and lysosomes, are known to operate as Ca(2+) storage sites in many cell types. This study demonstrates the presence of Ca(2+) stores in lysosomes of bovine corneal endothelial cells (BCECs) and examines their interaction with Ins(1,4,5)P(3)-sensitive Ca(2+) stores. METHODS Glycyl-L-phenylalanine-beta-naphthylamide (GPN) was used to release Ca...
متن کاملMaitotoxin converts the plasmalemmal Ca(2+) pump into a Ca(2+)-permeable nonselective cation channel.
Maitotoxin (MTX) activates Ca(2+)-permeable nonselective cation channels and causes a dramatic increase in cytosolic free Ca(2+) concentration ([Ca(2+)](i)) in every cell examined to date, but the molecular identity of the channels involved remains unknown. A clue came from studies of a structurally related marine toxin called palytoxin (PTX). PTX binds to the plasmalemmal Na(+)-K(+)-ATPase (NK...
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Genetic alterations in Ca(2+) channel subunits can be used to study the interaction among channel subunits and their roles in channel function. P/Q- and N-type Ca(2+) channels reside at the presynaptic terminal and control the release of neurotransmitter at mammalian central synapses. We used fluorescence imaging techniques to investigate presynaptic Ca(2+) currents and neurotransmitter release...
متن کاملTRPM2 Functions as a Lysosomal Ca-Release Channel in b Cells
D ow nloa TRPM2 is a Ca-permeable cation channel that is specifically activated by adenosine diphosphoribose (ADPR). Channel activation in the plasma membrane leads to Ca influx and has been linked to apoptotic mechanisms. The primary agonist, ADPR, is produced both extraand intracellularly and causes increases in intracellular calcium concentration ([Ca]i), but the mechanisms involved are not ...
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ژورنال
عنوان ژورنال: EMBO reports
سال: 2019
ISSN: 1469-221X,1469-3178
DOI: 10.15252/embr.201947953